Lakshmi Shankar Chaturvedi, PhD
Associate Professor of Clinical Research and Genetics
OFFICE:
San Joaquin General Hospital
Department of Surgery
500 West Hospital Road
French Camp, CA 95231
EDUCATION:
1986-1989 University of Allahabad, Allahabad, Uttar Pradesh (UP),
India Bachelor of Science (B.Sc.) in Botany and
Zoology as Major
1991-1993 Guru Nanak Dev University, Amritsar, India
Master of Science (M.Sc.) in Biotechnology
1995-2001 Doctor of Philosophy (PhD) in Genetics from Sanjay Gandhi Post-Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh (UP), India.
Mentor: Professor Balraj Mittal, Dept of Medical Genetics, SGPGIMS, Lucknow, UP, INDIA.
Title of PhD Thesis work: “Carrier analysis, prenatal diagnosis and point mutation studies in Duchenne/Becker muscular dystrophy (D/BMD)”.
PROFESSIONAL APPOINTMENTS:
December 2017-Present Associate Professor of Clinical Science and Genetics, Dept. of Pharmaceutical Sciences & Biomedical Sciences-College of Pharmacy and Dept. of Basic Sciences-College of Medicine, California Northstate University, Elk Grove, CA
December 2017-Present Research Director, San Joaquin General Hospital,
500 W. Hospital Road, French Camp, CA
August 2015-Dec 2017 Research Associate Professor, Department of Surgery, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND
October 2015-Present Research Associate Professor, Department of Pathology (Joint-appointment), School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND
November 2015-Present Research Assistant Professor, Department of Biomedical Sciences (Joint-appointment), School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND
August 2009-August 2015 Adjunct Assistant Professor, Department of Surgery,
College of Human Medicine, Michigan State University,
East Lansing, MI
August 2013- August 2015 Senior Research Associate, Department of
Surgery, College of Human Medicine, Michigan State University, Michigan State University, East Lansing, MI
August 2007-August 2013 Research Associate, Department of Anesthesiology and Surgery, Wayne State University, Detroit, MI
May 2003-August 2007 Postdoc Research Fellow, Department of
Anesthesiology and Surgery, Wayne State University, Detroit, MI
June 2000-April 2003 Postdoc Research Fellow, Department of Urology,
Henry Ford Health System, Detroit, MI
TEACHING SERVICES:
Year- 2016-2017 Teaching “Genetic Counselling-Talking to Families with Clinical Genetics perspective” to First Year UND Medical Student, Block-I
COMMUNITY SERVICES:
Year-2016-2017 Served as Judge for North Dakota State Science and
Engineering Fair (NDSSEF) on April 1, 2016
Year-2016-2017 Served as Judge for poster sessions for basic science and health science, UND on Frank Low Research Day on April 7th, 2016
MEMBER OF SEARCH COMMITTEES:
September 2015-Present Member of Search Committee for selection of
Junior Research Faculties in the Dept. of Surgery,
UND-SMHS
September 2015-Present Member of Search Committee for selection of
Research Associates/Post-Doctoral Fellows in the
Dept. of Surgery, UND-SMHS
MEMBER OF PROFESSIONAL SOCITIES:
ï 2018-Present: American association of Colleges of Pharmacy (AACP)
ï 2003-Present: American Lung Association (ALA)
ï 2001-Present: American Society of Nephrology (ASN)
ï 2000- Present: American Association for the Advancement of Science (AAAS)
ï 1996-Present: Life member of Indian Society of Human Genetics (ISHG)
REVIWER OF SCIENTIFIC JOURNALS:
ï Nature (Scientific Reports)
ï American Journal of Physiology (AJP)-Cell physiology
ï American Journal of Physiology (AJP)-Renal physiology
ï Biomed Research International Journal from Hindawi Publishing Corporation
Publications:
1. Basson, M.D., Chaturvedi, L.S., Wang, Q., Dekrey, E, Sun, K., Kuhn, L., Kovalenko, P., and Kiupel, M.. Schlafen 12 drives human enterocyte differentiation via interaction with Serpin B12 and deubiquitylases. J Clin Investigation (Under Review), 2017.
2. Katkoori, V., Manne, U., Chaturvedi L., Basson, M., Haan, P., Coffey, D., and Bumpers, H. Functional consequence of the p53 codon 72 polymorphism in Colorectal Cancer. Oncotarget (in Press), 2017.
3. Vyas D., Deshpande, K., Chaturvedi, L., Gieric, L., and Ching, K. Rapid
Extensive Recurrence of Triple Negative Breast Cancer: Are Both Therapy and Cancer Biology the Culprit? J Clin Med Res, 8(2):162-167, 2016.
4. Vyas, D., Lopez-Hisijos, L., Gandhi, S., El-Dakdouki, M., Basson, M.D.,
Walsh, M., Huang, X., Vyas, A and Chaturvedi, L.S. Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells. Journal of Nanoscience and Nanotechnology, 15(9):6413-6422, 2015.
5. Walsh, M.F., Hermann, R., Lee, J.H., Chaturvedi, L.S. and Basson, M.D.
Schlafen 3 Mediates the Differentiating Effects of Cdx2 in Rat IEC-Cdx2L1
Enterocytes. J Invest Surg. 28(4):202-207, 2015.
6. Chaturvedi, L., Sun, K., Walsh, M., Kuhn, L.A., and Basson, M.D. The P-
loop region of Schlafen 3 acts within cytosol to induce differentiation of human Caco-2 intestinal epithelial cells. BBA Molecular Cell Research Biochim Biophys Acta.1843(12):3029-37, 2014.
7. Chaturvedi, L.S. and Basson, M.D. The glucagon-like peptide-2 (GLP-2)
analog teduglutide stimulates proliferation but reduces differentiation in
human Caco-2 intestinal epithelial cells. JAMA Surg, 148(11):1037-42, 2013.
8. Chaturvedi, L.S., Zhang, P., Basson, M.D. Effects of extracellular pressure
and alcohol on the microglial response to inflammatory stimulation. Am J Surg, 204(5):602-6, 2012.
9. Kovalenko, P.L., Flanigan, T.L., Chaturvedi, L., Basson, M.D. Influence of defunctionalization and mechanical forces on intestinal epithelial wound healing. Am J Physiol Gastrointest Liver Physiol 303(10):G1134-43, 2012.
10. Chaturved,i L.S., Marsh, H.M., Basson, M.D. Role of RhoA and its effectors
ROCK and mDia1 in the modulation of deformation-induced FAK, ERK, p38, and MLC motogenic signals in human Caco-2 intestinal epithelial cells. Am J Physiol Cell Physiol 301(5):C1224-38, 2011.
11. Yu G., Dymond, M., Yuan, L., Chaturvedi, L.S., Shiratsuchi, H., Durairaj, S., Marsh, H.M., Basson, M.D. Propofol's effects on phagocytosis, proliferation, nitrate production, and cytokine secretion in pressure-stimulated microglial cells. Surgery 150(5):887-96, 2011.
12. Chaturvedi L.S., Saad, S.A., Bakshi, N., Marsh, H.M., Basson, M.D. Strain Matrix-Dependently Dissociates Gut Epithelial Spreading and Motility. J Surg Res 156(2):217-23, 2009.
13. Gayer,C.P., Chaturvedi, L.S., Wang, S., Alston, B., Basson, M.D. Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin. Am J Physiol Gastrointest Liver Physiol 296 (4):G867-85, 2009.
14. Gayer, C.P., Chaturvedi L.S., Wang, S., Craig, D.H., Flanigan, T., Basson, M.D. Strain-induced proliferation requires the PI3K/AKT/GSK pathway. J Biol Chem 284(4):2001-11, 2009.
15. Chaturvedi, L.S., Gayer, C.P., Marsh, H.M., and Basson, M.D. Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells. Am J Physiol Cell Physiol. 294(6):C1350-61, 2008.
